Housekeeping Genes

Housekeeping Genes. Biochemical studies on transcription initiation of the housekeeping gene promoters have been difficult, partly due to the less-characterized promoter motifs. Some genes, however, are constitutively expressed in all tissues and their expression levels are comparatively constant across different cell types

Housekeeping genes are typically constitutive genes that are required for the maintenance of basal cellular functions that are essential for the existence of a cell, regardless of its specific role in the tissue or organism The concept of "housekeeping gene" has been used for four decades but remains loosely defined

Godbey, in An Introduction to Biotechnology, 2014 4.2.3.2.1.2 CpG Islands The TATA box is not the only feature that can be used to identify the location of the gene Discover high quality siRNA Oligos for Knockdown of housekeeping genes in human, mouse and rat! Biochemical studies on transcription initiation of the housekeeping gene promoters have been difficult, partly due to the less-characterized promoter motifs.

. The searching of human housekeeping (HK) genes has been a long quest since the emergence of transcriptomics, and is instrumental for us to understand the structure of genome and the fundamentals of biological processes Housekeeping genes are of broad interest for translational and basic science research

. Biochemical studies on transcription initiation of the housekeeping gene promoters have been difficult, partly due to the less-characterized promoter motifs. Introduction Housekeeping genes are often defined as being stably expressed in all cells and conditions [1], essential [2], belong to cellular maintenance pathways [1,3-6] and be conserved [7,8]